Spasrine tablets

Key Attributes.

Each film coated tablet contains: Drotaverine HCl. I.P. 80 mg. Mefenamic Acid I.P. 250mg. Drotaverine is a spasmolytic agent which acts directly on smooth muscle cells. Drotaverine inhibits the Phosphodiesterase enzyme which leads to an increase of the cAMP level producing smooth muscle cell relaxation. It is thought that Drotaverine also inhibits the initial calcium uptake of the cell. Drotaverine is characterized by a rapid onset of action which is very advantageous in case of acute painful spastic conditions. Because of its direct action on smooth muscle, Drotaverine does not affect the autonomic nervous system. There fore, it is free of the side effects associated with anticholinergic antispasmodics and can be used in glaucoma and prostatic hypertrophy. Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain. Mefenamic acid decreases inflammation (swelling) and uterine contractions