Methotrexate

Key Attributes.

"High Quality Methotrexate with Good Price (CAS 59-05-2) Quick Details: Methotrexate CAS : 59-05-2 Brand: NEWBIO MW: C20H22N8O5 MSDS: Avaiable MF : 454.44 Sample: Avaiable Category: Oncology drug Min order: 10grams Quality standard:   USP   EP Place of Origin:China Introduction used as anti-tumour medicament. Character Orange-yellow ,crystalline powder Applications Pharmaceutical raw materials , Oncology drug Product Description: Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate. COA: Text USP27 EP4 BP2002 Assay% 98.0-102.0 98.0-102.0 98.0-102.0 Residue on ignition% ≤0.1     Specific roataion +19-+24 +19-+24   Loss on drying%       Chromatographic purity% ≤2.0(total)       ≤0.5(individual)     Water% ≤12.0 ≤13.0 ≤12.0 Organic Volatile impurites conforms Sulphated ash%   ≤0.1 ≤0.1 Heavy metals ppm   50 1 Related substance       Total   ≤1.3 ≤1.3% Individual   At most five peaks At most five peaks Impurity A%   ≤0.5 ≤0.5 Impurity B%   ≤0.5 ≤0.5 Impurity C%   ≤0.5 ≤0.5 Impurity D%   ≤0.5 ≤0.5 Impurity E%   ≤0.5 ≤0.5 Unknown Impurity %   ≤0.5 ≤0.5 (R)-Methotrexate%   ≤3.0 ≤3.0 FEATURED PRODUCT: Wuhan Newbio Pharm-tech Co., Ltd. S# CAS No. Product Name S# CAS No. Product Name 1  86639-52-3 7-Ethyl-10-Hydroxycamptothecin 25  183321-74-6 Erlotinib 2  154229-18-2 Abiraterone Acetate 26  183319-69-9 Erlotinib Hydrochloride 3  50-76-0 Actinomycin D 27  159351-69-6 Everolimus 4  106941-25-7 Adefovir 28  56296-78-7 Fluoxetine Hydrochloride 5  850140-72-6 Afatinib 29  184475-55-6 Gefitinib Hydrochloride 6  330784-47-9 Avanafil 30  136572-09-3 Irinotecan Hydrochloride TriHydrate 7  319460-85-0 Axitinib 31  1441674-54-9 Ledipasvir(Acetone) 8  1421373-66-1 AZD-9291 (Mesylate) 32  191732-72-6 Lenalidomide 9  123524-52-7 Azelnidipine 33  21672  Methotrexate 10  863031-21-4 Azilsartan Medoxomil 34  76144-81-5 Mildronate 11  179324-69-7 Bortezomib 35  474645-27-7 Monomethyl Auristatin E 12  357336-20-0 Brivaracetam 36  63121-00-6 Oxaliplatin 13  842133-18-0 Canagliflozin 49  33069-62-4 Paclitaxel 14  928672-86-0 Canagliflozin HemiHydrate 37  137281-23-3 Pemetrexed Disodium 15  41575-94-4 Carboplatin 38  53123-88-9 Rapamycin 16  50935-04-1 Carubicin 50  135062-02-1 Repaglinide 17  288383-20-0 Cediranib 39  945667-22-1 Saxagliptin Hydrate 18  15663-27-1 Cisplatin 40  709031-78-7 Saxagliptin Hydrochloride 19  877399-52-5 Crizotinib 41  486460-32-6 Sitagliptin 20  171500-79-1 Dalbavancin 42  654671-77-9 Sitagliptin Phosphate Hydrate 21  114977-28-5 Docetaxel 44  85622-93-1 Temozolomide 22  148408-66-6 Docetaxel TriHydrate 45  477600-75-2 Tofacitinib 23  25316-40-9 Doxorubicin hydrochloride 46  540737-29-9 Tofacitinib Citrate 24  133040-01-4 Eprosartan 47  170791-09-0 Trityl Candesartan Cilexetil ABOUT DELIVERY: #1 Products can be sent out within 24 hours after payment.  #2 Secure and discreet shipment.  #3 Various methods for your choice, like DHL/FedEx/SF-express. OUR COMMITMENT: #1 We are manufacturer with own factory and we sale this product at a best quality and low price. #2 All product listed is available in stock, please contact the sale for more details. #3  We have QA&QC department to guarantees the quality, product pass rate can reach 100%.  CONTACT US: Telephone +86-027-87002705 Mobile +86-13277093700 +86-13638641831   newbiopharmtech FaceBook Page https://www.facebook.com/newbiopharma/ Facebook Group https://www.facebook.com/groups/1739616069613416/ Website http://www.newbiopharm.com/ Online Store http://biocar.en.made-in-china.com/ If you want to source ...         #1 Pharmaceutical raw material,         #2 Oncology drug APIs,         #3 Antibiotics or fine chemicals,  We are a reliable manufacturer and supplier in China. NEWBIO would like to ...         #1 We foucus on the high purity and high quality;         #2 We provide the raw materials at a good price;         #3 We have the best service and we are always there for you. Please contact us for more infomation!!!"